Nariko Arimura

Department of Pharmacology,

Graduate School of Pharmaceutical Sciences,

Tohoku University,

Associate Professor

Career

2022–Present
Associate Professor, Graduate School of Pharmaceutical Sciences, Tohoku University

2020–2022
Research Fellow, National Center of Neurology and Psychiatry

2017–2020
JSPS Research Fellow for Young Scientists (RPD)

2013–2017
Researcher, National Center of Neurology and Psychiatry

2011–2012
Chief Researcher, Tokyo Metropolitan Institute of Medical Science

2008–2011
Associate Professor, Global COE Program, Tamagawa University

2005–2008
Assistant Professor, Graduate School of Medicine, Nagoya University

2003–2004
JSPS Postdoctoral Fellow (PD)

Academic Background

2004–2007

Ph.D. in Medicine, Graduate School of Medicine, Nagoya University

2000–2003

M.S. in Biological Sciences, Graduate School of Biological Sciences, Nara Institute of Science and Technology

1998–2000

B.S. in Biology, Faculty of Science, Kyushu University

1994–1998

Kawashima Gakuen Reimei High School

Committee and Journal Editorial Board Member History

2025–Present

Member, Future Programs Committee, The Japan Society for Divine Chemistry

2025–Present

Section Editor / Editorial Board Member, Discover Neuroscience (Springer Nature)

2024–Present

Associate Editor, Frontiers in Neuroscience (Neuroscience Methods and Techniques section)

2022–2024

Associate Editor, Frontiers in Genetics, Neuroscience, and Neurology (Neurogenomics section)

2021–2023

Member, Diversity Promotion Committee, Japanese Society for Neurochemistry

2021–2023

Member, Symposium Planning Committee, Japanese Society for Neurochemistry

Research Projects

Our research aims to elucidate the mechanisms underlying brain function, identify changes associated with pathological conditions, and explore potential therapeutic approaches. Currently, we are pursuing three main projects:

1) Molecular mechanisms of brain development

2) Dementia and bone marrow transplantation

3) Brain injury and functional compensation

Molecular mechanisms of brain development

Young neurons generated in the deeper regions of the brain begin migrating toward the more superficial layers shortly after their birth. Upon reaching their appropriate destinations, they initiate the formation of neural circuits. While this process appears to be an intrinsic property of neurons, much remains unknown about how they navigate to the correct location and how they determine their synaptic partners. By investigating the developmental processes of the fetal brain, we aim to uncover the fundamental principles underlying neural network formation.

Dementia and bone marrow transplantation

With the rapid aging of the population in recent years, the development of therapeutic agents for dementia and Alzheimer’s disease has become increasingly important. Dementia is believed to begin developing decades before the onset of clinical symptoms, making its prevention particularly challenging. While various studies have explored the underlying causes of the disease, our research focuses on blood-borne factors involved in dementia in order to elucidate its pathogenesis and explore the potential for therapeutic intervention. As part of this work, we are investigating how changes in blood composition—specifically those resulting from bone marrow–derived hematopoietic stem cells—affect the restoration of brain function.

Brain injury and functional compensation

The brain's functions and neural circuits are highly flexible, allowing individuals to adapt their behavior to achieve intended actions, such as playing a musical instrument or engaging in sports. However, the underlying neural mechanisms that enable such flexibility remain incompletely understood. Our research aims to elucidate the mechanisms of functional enhancement through processes such as activity-dependent gene expression, changes in neuronal excitability, and the reorganization of neural circuits. In particular, we are investigating how other brain regions respond when a specific area is damaged, and how these compensatory changes contribute to the acquisition of new functions and functional recovery.

Recent Papers and Reviews

Front Neurosci. 2024 Apr 17:18:1360432.

Yagishita et al. developed an in vivo electrophysiology-based single-cell RNA sequencing approach to reveal that gene expression profiles in hippocampal pyramidal neurons are significantly correlated with their spike properties, providing a framework for linking neuronal physiology and transcriptional identity.

Nat Commun. 2024 Feb 1;15(1):458.

We show that DSCAM in Purkinje cells regulates cerebellar synapse formation and function by interacting with the astrocytic glutamate transporter GLAST, thereby coordinating glutamate clearance and synaptic organization at peri-synaptic contacts.

Sci Adv. 2020 Sep 2;6(36):eaba1693.

We demonstrate that DSCAM regulates neuronal delamination during early brain development by locally suppressing the RapGEF2–Rap1–N-cadherin signaling cascade at the apical endfeet, thereby controlling ventricular detachment of differentiating neurons.

Neurosci Res. 2024 May;202:1-7.

This review highlights the multifunctional roles of DSCAM in both Drosophila and vertebrates, emphasizing its species-specific regulation of intercellular adhesion and synaptogenesis, and aims to clarify the distinct molecular interactions that underlie its context-dependent adhesive functions.

Neurosci Res. 2023 Feb;187:14-20.

This review explores the roles of adhesion molecules in mediating astrocyte-neuron interactions during neural circuit and synapse formation, particularly in the cerebellum, and introduces a novel mechanism of tripartite synapse regulation recently identified by our group.

Genes Cells. 2019 Jan;24(1):41-59.

This study redefines the layer structure of the embryonic dorsal midbrain using molecular markers of proliferation and differentiation, providing a framework for analyzing the development, proliferation, and migration of glutamatergic and GABAergic neurons in this region.

Member

We are currently conducting research with 7 students.

We are always looking for people who would like to do research with us.

The following photos are of the Department of Pharmacology. (Professor Takuya Sasaki is on the left)

Associate Professor
Nariko Arimura (front row, far right)
Email: nariko.arimura.a2[at]tohoku.ac.jp

Master’s Program, 2nd Year
Riku Ogawa

Kento Tobisawa (Excellent Graduate School Program)

6th-Year Undergraduate Student (Faculty of Pharmaceutical Sciences)
Kazutaka Sugawara

Master’s Program, 1st Year
Toshimichi Nakazawa
Yugo Wada

4th-Year Undergraduate Students
Goro Ikeda
Keigo Yokokawa

My Lecture Activities

Nariko Arimura, Exploration of plasma components that regulate cognitive function, Symposium on Biological Function and Drug Discovery 2025 (Sendai), August 28, 2025.
Nariko Arimura, Exploration of blood components in mouse models of Down syndrome that affect cognitive function, The 4th Basic Research Meeting on Down Syndrome (Ise), July 27, 2025.
N. Arimura, Circuit network formation generated by membrane molecular interactions between neurons and glial cells, 98th Annual Meeting of the Japanese Pharmacological Society (Makuhari), March 17, 2025.
N. Arimura, From cell to brain: a multifaceted approach to understanding brain function, Invited talk at the 42nd Institute of Neurology Molecular Circuitry Seminar, National Center of Neurology and Psychiatry, March 5, 2025.
N. Arimura, Various functions of the neuronal membrane molecule DSCAM during development, 47th Annual Meeting of the Molecular Biology Society of Japan, Fukuoka, Japan, November 29, 2024.
Nariko Arimura, Multifaceted Functions of the Adhesion Molecule DSCAM in Neural Development, Symposium, 47th Annual Meeting of the Japan Neuroscience Society, Fukuoka, Japan, July 25, 2024
Nariko Arimura, Investigating the cognitive and molecular impact of Down Syndrome bone marrow transplantation. Brain Research Institute, Niigata University), March 15, 2025
Nariko Arimura, DSCAM as a Key Regulator of Neural Delamination and Synaptic Connectivity. Riken), January 24, 2025
N. Arimura, Analysis of the Mechanism of Dementia Induced by Bone Marrow Transplantation, 97th Annual Meeting of the Japanese Pharmacological Society (Hyogo), Symposium, Chair, December 15, 2023
N. Arimura, Elucidation of the pathogenesis of dementia mediated by hematopoietic stem cells, 46th Annual Meeting of the Japanese Society for Neurotissue Culture, Kanagawa, Japan, Symposium, December 2, 2023.
Nariko Arimura, Bone-marrow-derived cells in trisomy are implicated in dementia, 46th Annual Meeting of the Japan Neuroscience Society, Sendai, Japan, Symposium, August 1, 2023
Nariko Arimura, From Marrow to Memory: Tracing Dementia Onset using Down Syndrome Model Mice. The Core to Core Program Symposium (IRCMS, Kumamoto University), February 20, 2024
Nariko Arimura, Graduate School of Medicine, Tottori University, March 18, 2024
N. Arimura, Functional Regulation of Glial Cell Membrane Molecule GLAST by Neural Adhesion Molecule DSCAM, Symposium at 128th Annual Meeting of the Japanese Society of Anatomy, Sendai, March 18, 2023
N. Arimura, Exploration of new blood-derived components causing dementia, The 7th Symposium of the Research Center for Drug Development, Sendai, March 7, 2023, Symposium
N. Arimura, Functional analysis of Down syndrome-related factor DSCAM at cerebellar synapses, 95th Annual Meeting of the Japanese Biochemical Society (Nagoya) November 11, 2022, Symposium
N. Arimura, Various functions of the neuronal membrane molecule DSCAM: from the viewpoint of neuronal migration and synapses, ICBS Seminar, Fujita Medical College (Toyoake), November 8, 2022, Invited talk

Conference presentations by research members

2025

Ogawa, R., Sasaki, T., Arimura, N. (2025, July 24). Analysis of the mechanism of dementia development using blood cell transplantation in Down syndrome model mice. 48th Annual Meeting of the Japan Neuroscience Society, Niigata, Japan. Poster Presentation, 1P-225.
Sugahara, K., Honjyoya, N., Kayama, T., Sasaki, T., Arimura, N. (2025, July 24). Elucidation of functional recovery mechanisms after cerebellar injury by whole-brain electrophysiological measurements. 48th Annual Meeting of the Japan Neuroscience Society, Niigata, Japan. Poster Presentation, 1P-096. Best Presentation Award.
Nakazawa, S., Sasaki, T., Arimura, N. (2025, July 24). Effects of bone marrow transplantation on age-related cognitive decline in young mice. 48th Annual Meeting of the Japan Neuroscience Society, Niigata, Japan. Poster Presentation, 1P-222. Best Presentation Award.
Hizawa, K., Inoue, Y., Miyashita, S., Inoue, T., Ikuta, T., Sasaki, T., Hoshino, M., Arimura, N. (2025, July 24). Analysis of the regulatory mechanism of intercellular adhesion by the neural adhesion factor DSCAM. 48th Annual Meeting of the Japan Neuroscience Society, Niigata, Japan. Poster Presentation, 1P-005.
Wada, Y., Honjyoya, N., Kayama, T., Sasaki, T., Arimura, N. (2025, July 24). Functional coupling analysis of motor networks in cerebellar injury. 48th Annual Meeting of the Japan Neuroscience Society, Niigata, Japan. Poster Presentation, 1P-104. Best Best Presentation Award.
Nakazawa, S., Ogawa, R., Sasaki, T., Arimura, N. (2025, March 28). Analysis of dementia pathogenesis mechanisms focusing on blood components. 145th Annual Meeting of the Pharmaceutical Society of Japan, Fukuoka, Japan. Poster Presentation, 28P-am319S. Best Presentation Award.

2024

Hizawa, K., Inoue, Y., Miyashita, S., Inoue, T., Sasaki, T., Hoshino, M., Arimura, N. (2024, September 28–29). Analysis of the regulatory mechanism of intercellular adhesion by the neural adhesion factor DSCAM. 30th Annual Conference on Hippocampus and Higher Brain Functions, Tokyo, Japan. Oral Presentation.
Wada, Y., Sugawara, K., Honjyoya, N., Sasaki, T., Arimura, N. (2024, September 21). Longitudinal EEG analysis of regions related to motor function during cerebellar injury. 75th Annual Meeting of the Japanese Pharmacological Society for Northern Japan, Iwate, Japan. Oral Presentation, A1-02. Best Presentation Award.
Hizawa, K., Inoue, Y., Miyashita, S., Inoue, T., Sasaki, T., Hoshino, M., Arimura, N. (2024, August 31). Analysis of the regulatory mechanism of intercellular adhesion by the neural adhesion factor DSCAM. Drug Discovery and Medical Pharmacology Symposium for Young Leaders of the Next Generation 2024, Osaka, Japan. Poster Presentation, P4. Best Presentation Award.
Hizawa, K., Inoue, Y., Miyashita, S., Inoue, T., Sasaki, T., Hoshino, M., Arimura, N. (2024, August 29–30). Analysis of the regulatory mechanism of intercellular adhesion by the neural adhesion factor DSCAM. Symposium on Biological Function and Drug Discovery 2024, Kyoto, Japan. Poster Presentation, P2-3.
Arimura, N. (2024, July 28). Exploration of blood components in mouse models of Down syndrome that affect cognitive function. 3rd Basic Research Meeting on Down Syndrome, Nagoya, Japan. Oral Presentation.
Hizawa, K., Inoue, Y., Miyashita, S., Inoue, T., Sasaki, T., Hoshino, M., Arimura, N. (2024, July 24). Functional analysis of the neuronal membrane molecule DSCAM using ultra-high affinity ALFA-tag nanobodies. NEURO2024, Fukuoka, Japan. Poster Presentation, 1P-010. Poster Award for Junior Researchers.
Yagishita, H., Okamoto, K., Go, Y., Arimura, N., Ikegaya, Y., Sasaki, S. (2024, June 27). Gene expressions related to hippocampal ripples. FENS Forum 2024, Vienna, Austria. Poster Presentation, 1760. FENS Forum 2024 Travel Award.
Hizawa, K., Inoue, Y., Miyashita, S., Inoue, T., Sasaki, T., Hoshino, M., Arimura, N. (2024, March 30). Functional analysis of the neuronal membrane molecule DSCAM using the highly sensitive epitope tag ALFA. 144th Annual Meeting of the Pharmaceutical Society of Japan, Yokohama, Japan. Poster Presentation, 30P-pm176S.

2023

Ogawa, R., Sasaki, T., Arimura, N. (2023, December 16). Analysis of the mechanism of dementia development using bone marrow cells from Down syndrome model mice. 97th Annual Meeting of the Japanese Pharmacological Society, Kobe, Japan. Poster Presentation, 3-B-P-085. Best Presentation Award.
Yagishita, H., Okamoto, K., Go, Y., Arimura, N., Ikegaya, Y., Sasaki, S. (2023, November 14). A method to analyze gene expression profiles of a hippocampal neuron recorded from head-fixed mice. Society for Neuroscience Annual Meeting, Washington, D.C., USA. Poster Presentation, PSTR 444.05.
Honjyoya, N., Sugawara, K., Sasaki, T., Arimura, N. (2023, September 23). Analysis of the mechanism of motor function recovery and whole-brain neuronal circuit reorganization after cerebellar injury. 74th Annual Meeting of the Japanese Society of Pharmacology Northern Meeting, Akita, Japan. Oral Presentation, B07. Best Presentation Award.
Yagishita, H., Okamoto, K., Go, Y., Arimura, N., Ikegaya, Y., Sasaki, S. (2023, September 29). Exploration of genes expressed in association with in vivo firing properties of hippocampal neurons. 29th Hippocampus and Higher Order Function Conference, Tokyo, Japan. Oral Presentation.
Ogawa, R., Sasaki, T., Arimura, N. (2023, August 24). Analysis of the mechanism of dementia development using bone marrow cells from Down syndrome model mice. Symposium on Biological Function and Drug Discovery 2023, Tokushima, Japan. Poster Presentation, P11-A.
Ogawa, R., Sasaki, T., Arimura, N. (2023, July 23). Analysis of the mechanism of onset of dementia using bone marrow cells from Down syndrome model mice. 2nd Basic Research Meeting of the Down Syndrome Society, Kumamoto, Japan. Poster Presentation.
Arimura, N. (2023, July 22). Analysis of the mechanism of cognitive function modification by bone marrow transplantation. 2nd Basic Research Meeting of Down Syndrome, Kumamoto, Japan. Oral Presentation.
Honjyoya, N., Sugawara, K., Sasaki, T., Arimura, N. (2023, March 18). Mechanisms of functional recovery and whole-brain neural circuit reorganization in cerebellar injury. 128th Annual Meeting of the Japanese Association of Anatomists, Sendai, Japan. Poster Presentation, 1STP-016.

Personal and Team Background

I am a neuroscientist and mother of two wonderful daughters. Currently, I reside in Sendai-shi in Miyagi. In my free time, I enjoy reading ‘bunkoban’ novels, watching movies, and window shopping. When I was a high school student, I wanted to be a foreign diplomat because I wanted to travel abroad, but thought it would be too difficult, so I decided to be a neuroscientist instead. I love travelling and have been to San Diego and Washington in the USA, Lion in France, Beijing in China, and Lisbon in Portugal. Someday I hope to visit Brazil and Singapore.

Typically, our team consists of seven researchers. We are researching three studies concernig brain function and development. Please see the details of our research below. Our team has published several papers on our research and we recently presented at a symposium online. We are looking for overseas partners to cooperate with us on…

Publication

A method to analyze gene expression profiles from hippocampal neurons electrophysiologically recorded in vivo.

Yagishita H, Go Y, Okamoto K, Arimura N, Ikegaya Y, Sasaki T.

Front Neurosci. 2024 Apr 17;18:1360432. doi: 10.3389/fnins.2024.1360432.

Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.

Dewa KI, Arimura N, Kakegawa W, Itoh M, Adachi T, Miyashita S, Inoue YU, Hizawa K, Hori K, Honjoya N, Yagishita H, Taya S, Miyazaki T, Usui C, Tatsumoto S, Tsuzuki A, Uetake H, Sakai K, Yamakawa K, Sasaki T, Nagai J, Kawaguchi Y, Sone M, Inoue T, Go Y, Ichinohe N, Kaibuchi K, Watanabe M, Koizumi S, Yuzaki M, Hoshino M.

Nat Commun. 2024 Feb 1;15(1):458. doi: 10.1038/s41467-023-44579-z.

A comparative overview of DSCAM and its multifunctional roles in Drosophila and vertebrates.

Hizawa K, Sasaki T, Arimura N.

Neurosci Res. 2024 May;202:1-7. doi: 10.1016/j.neures.2023.12.005. Epub 2023 Dec 21.

Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.

Wang H, Fukunaga K, Cheng A, Wang Y, Arimura N, Yoshino H, Sasaki T, Kawahata I.

J Pharmacol Sci. 2023 May;152(1):30-38. doi: 10.1016/j.jphs.2023.02.008. Epub 2023 Mar 11.

Neuronal and astrocytic protein connections and associated adhesion molecules.

Dewa KI, Arimura N.

Neurosci Res. 2023 Feb;187:14-20. doi: 10.1016/j.neures.2022.09.014. Epub 2022 Oct 3.

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication.

Yamashiro K, Hori K, Lai ESK, Aoki R, Shimaoka K, Arimura N, Egusa SF, Sakamoto A, Abe M, Sakimura K, Watanabe T, Uesaka N, Kano M, Hoshino M.

iScience. 2020 Nov 18;23(12):101820. doi: 10.1016/j.isci.2020.101820. eCollection 2020 Dec 18.

DSCAM regulates delamination of neurons in the developing midbrain.

Arimura N, Okada M, Taya S, Dewa KI, Tsuzuki A, Uetake H, Miyashita S, Hashizume K, Shimaoka K, Egusa S, Nishioka T, Yanagawa Y, Yamakawa K, Inoue YU, Inoue T, Kaibuchi K, Hoshino M.

Sci Adv. 2020 Sep 2;6(36):eaba1693. doi: 10.1126/sciadv.aba1693. Print 2020 Sep.

Comprehensive and cell-type-based characterization of the dorsal midbrain during development.

Arimura N, Dewa KI, Okada M, Yanagawa Y, Taya SI, Hoshino M.

Genes Cells. 2019 Jan;24(1):41-59. doi: 10.1111/gtc.12656. Epub 2018 Dec 5.

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.

Watanabe T, Kakeno M, Matsui T, Sugiyama I, Arimura N, Matsuzawa K, Shirahige A, Ishidate F, Nishioka T, Taya S, Hoshino M, Kaibuchi K.

J Cell Biol. 2015 Aug 31;210(5):737-51. doi: 10.1083/jcb.201412075.

10.

Involvement of the globus pallidus in behavioral goal determination and action specification.

Arimura N, Nakayama Y, Yamagata T, Tanji J, Hoshi E.

J Neurosci. 2013 Aug 21;33(34):13639-53. doi: 10.1523/JNEUROSCI.1620-13.2013.

11.

Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases.

Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto MR, Tokumitsu H, Soderling TR, Sakakibara A, Miyata T, Kamiguchi H, Kaibuchi K.

Sci Signal. 2011 Nov 15;4(199):ra76. doi: 10.1126/scisignal.2002011.

12.

[Neural mechanisms underlying the integration of perception and action].

Hoshi E, Nakayama Y, Yamagata T, Saga Y, Hashimoto M, Arimura N, Tanji J.

Brain Nerve. 2011 Jan;63(1):59-68. Review. Japanese.

13.

CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity.

Arimura N, Hattori A, Kimura T, Nakamuta S, Funahashi Y, Hirotsune S, Furuta K, Urano T, Toyoshima YY, Kaibuchi K.

J Neurochem. 2009 Oct;111(2):380-90. doi: 10.1111/j.1471-4159.2009.06317.x. Epub 2009 Jul 31.

14.

TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.

Iguchi Y, Katsuno M, Niwa JI, Yamada SI, Sone J, Waza M, Adachi H, Tanaka F, Nagata KI, Arimura N, Watanabe T, Kaibuchi K, Sobue G.

J Biol Chem. 2009 Aug 14;284(33):22059-22066. doi: 10.1074/jbc.M109.012195. Epub 2009 Jun 17.

15.

Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.

Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K.

Dev Cell. 2009 May;16(5):675-86. doi: 10.1016/j.devcel.2009.03.005.

16.

[Neuronal polarity].

Arimura N, Yoshimura T, Kaibuchi K.

Tanpakushitsu Kakusan Koso. 2008 Mar;53(4 Suppl):386-92.

PMID: 21089308 Review. Japanese. No abstract available.

17.

Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2.

Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H, Araki N.

J Biol Chem. 2008 Apr 4;283(14):9399-413. doi: 10.1074/jbc.M708206200. Epub 2008 Jan 23.

18.

[Molecular mechanisms regulating neuronal polarity via phosphorylation signaling].

Yoshimura T, Arimura N, Hattori A, Kaibuchi K.

Tanpakushitsu Kakusan Koso. 2007 Jun;52(7):753-9.

19.

Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.

Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, Nakayama M, Hoshino M, Iwamatsu A, Murohara T, Kaibuchi K, Amano M.

Biochem Biophys Res Commun. 2007 Apr 13;355(3):788-94. doi: 10.1016/j.bbrc.2007.02.028. Epub 2007 Feb 14.

20.

Neuronal polarity: from extracellular signals to intracellular mechanisms.

Arimura N, Kaibuchi K.

Nat Rev Neurosci. 2007 Mar;8(3):194-205. doi: 10.1038/nrn2056.Review.

21.

IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.

Wang S, Watanabe T, Noritake J, Fukata M, Yoshimura T, Itoh N, Harada T, Nakagawa M, Matsuura Y, Arimura N, Kaibuchi K.

J Cell Sci. 2007 Feb 15;120(Pt 4):567-77. doi: 10.1242/jcs.03356. Epub 2007 Jan 23.

22.

Molecular mechanisms of axon specification and neuronal disorders.

Yoshimura T, Arimura N, Kaibuchi K.

Ann N Y Acad Sci. 2006 Nov;1086:116-25. doi: 10.1196/annals.1377.013. Review.

23.

Signaling networks in neuronal polarization.

Yoshimura T, Arimura N, Kaibuchi K.

J Neurosci. 2006 Oct 18;26(42):10626-30. doi: 10.1523/JNEUROSCI.3824-06.2006. Review.

24.

[Neuronal polarity].

Arimura N, Yoshimura T, Kaibuchi K.

Tanpakushitsu Kakusan Koso. 2006 May;51(6 Suppl):789-95.Review.

25.

Vimentin-Ser82 as a memory phosphorylation site in astrocytes.

Oguri T, Inoko A, Shima H, Izawa I, Arimura N, Yamaguchi T, Inagaki N, Kaibuchi K, Kikuchi K, Inagaki M.

Genes Cells. 2006 May;11(5):531-40. doi: 10.1111/j.1365-2443.2006.00961.x.

26.

Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism.

Mimura F, Yamagishi S, Arimura N, Fujitani M, Kubo T, Kaibuchi K, Yamashita T.

J Biol Chem. 2006 Jun 9;281(23):15970-9. doi: 10.1074/jbc.M510934200. Epub 2006 Apr 4.

27.

Key regulators in neuronal polarity.

Arimura N, Kaibuchi K.

Neuron. 2005 Dec 22;48(6):881-4. doi: 10.1016/j.neuron.2005.11.007. Review.

28.

Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway.

Yoshimura T, Arimura N, Kawano Y, Kawabata S, Wang S, Kaibuchi K.

Biochem Biophys Res Commun. 2006 Feb 3;340(1):62-8. doi: 10.1016/j.bbrc.2005.11.147. Epub 2005 Dec 6.

29.

Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.

Arimura N, Ménager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M, Goshima Y, Inagaki M, Morone N, Usukura J, Kaibuchi K.

Mol Cell Biol. 2005 Nov;25(22):9973-84. doi: 10.1128/MCB.25.22.9973-9984.2005.

30.

[Molecular mechanisms of neuronal polarity].

Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kaibuchi K.

Nihon Shinkei Seishin Yakurigaku Zasshi. 2005 Aug;25(4):169-74. Review. Japanese.

31.

GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.

Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K.

Cell. 2005 Jan 14;120(1):137-49. doi: 10.1016/j.cell.2004.11.012.

32.

PIP3 is involved in neuronal polarization and axon formation.

Ménager C, Arimura N, Fukata Y, Kaibuchi K.

J Neurochem. 2004 Apr;89(1):109-18. doi: 10.1046/j.1471-4159.2004.02302.x.

33.

Role of CRMP-2 in neuronal polarity.

Arimura N, Menager C, Fukata Y, Kaibuchi K.

J Neurobiol. 2004 Jan;58(1):34-47. doi: 10.1002/neu.10269. Review.

34.

CRMP-2 induces axons in cultured hippocampal neurons.

Inagaki N, Chihara K, Arimura N, Ménager C, Kawano Y, Matsuo N, Nishimura T, Amano M, Kaibuchi K.Nat Neurosci. 2001 Aug;4(8):781-2. doi: 10.1038/90476.

35.

Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.

Arimura N, Inagaki N, Chihara K, Ménager C, Nakamura N, Amano M, Iwamatsu A, Goshima Y, Kaibuchi K.J Biol Chem. 2000 Aug 4;275(31):23973-80. doi: 10.1074/jbc.M001032200.

Contact information

Nariko Arimura, Ph.D.